Nate Dwarshuis


Graduate Research Assistant

Office: EBB 3110

Research Focus: Adoptive cell therapy using CAR T cells show immense promise for treating various cancers, but we currently lack the ability to a) expand CAR T cells to high quality, clinically useful populations, and b) reliably predict anti-tumor potency after expansion. Problematically, current expansion protocols do not fully exploit the way T cells are expanded in vivo, and current anti-tumor assays fail to account for key features in the tumor microenvironment. We aim to enhance expansion using functionalized microenvironments to mimic the secondary lymphoid organs. Additionally, we aim to develop a more physiologically relevant tumor model to evaluate anti-tumor potency; this will then be correlated to a set of biomarkers to create a predictive model.